Metastasis of malignant tumors to the oral cavity: Systematic review of case reports and case series.

OBJECTIVE: To summarize published information regarding malignant tumors with metastasis to the oral cavity. MATERIALS AND METHODS: This was a systematic review with meta-analysis. An electronic search of Pubmed, Scopus, and Google Scholar databases from inceptions to February 2022 were performed. Only case reports or case series with histopathological results demonstrating metastasis to the oral cavity were included. The main outcomes included demographics, primary site, metastatic site, clinical manifestations, and patient survival. The quality of primary articles was assessed using the Joanna Briggs Institute - University of Adelaide scorecards for case reports and case series. Descriptive analysis and a Kaplan-Meier survival curve were performed. RESULTS: 273 articles were selected (50 case series and 223 case reports), for a total of 950 cases. The mean age was 57.11 years. Males were more affected (57.5%). The most common primary sites in women and men was breast (29.8%), and lung (24.8%), respectively. In ∼1/3 of the cases, oral metastasis preceded tumor dissemination. Jawbones were more affected (56.7%) than soft tissues (37.9%), with the mandible being the most affected site (45.5%), followed by the gingiva (19.9%). The most common clinical manifestation was a mass or nodule. Most radiographic evidence was radiolucency of the jaw (60.6%). 3-year and 5-year survival rates were 14.2 and 10.7%. In the majority of cases, the primary tumor was the first to be diagnosed, while in 30.4%, metastasis was the first sign of the disseminated disease. This can be implied that the oral metastasis should be included in the differential diagnosis list of the oral diseases. CONCLUSION: Clinicians should be aware of the possibility of, albeit uncommon, oral metastases. Because the extracted data in this review was relatively generalized, the investigators cannot develop the diagnostic clues of oral metastasis, which require further investigations.

Validation of a Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire

Background: The aim of this study was to validate and determine at pretest level the reliability of the Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire. Material and methods: This study employed 37 head and neck cancer patients. Each patient signed an informed consent and responded to the Portuguese version of the questionnaire in the form of an interview. This was repeated again after 2 weeks. A standard single question provided a validity check. Data were analyzed using Cronbach's α to test its reliability and total and interitem correlation, and intraclass correlation to determine its internal consistency and test-retest reliability. Construct validity supported by objective measurements as salivary secretion was also investigated. Significance was set at .05. Results: Cronbach's α was 0.91 and 0.89 for the first and second test administrations, respectively, which indicates that the internal consistency was excellent. The intraclass correlation coefficient value for the test-retest reliability was 0.70. The correlation between the total score of the questionnaire and standard single dry mouth question was 0.72 for the first round, indicating a good correlation. Conclusions: Demonstrating very good psychometric properties, the Portuguese version of the Groningen radiotherapy-induced xerostomia questionnaire is a valid tool and can be considered a reliable instrument to measure xerostomia in head and neck cancer patients. (AU)

Oral biopsies in a Portuguese population: A 20-year clinicopathological study in a university clinic.

Background: Performing a biopsy is very important in oral medicine and the anatomopathological examination is fundamental to obtain or to confirm the diagnosis in oral and maxillofacial pathology. The purpose of this study is to analyse the frequency and characteristic patterns of biopsied oromaxillofacial lesions in a Portuguese population. Material and Methods: A descriptive statistical analysis of the data from the anatomopathological reports of the biopsies performed between 1999 and 2019 at the university clinic of the Faculty of Dental Medicine of the University of Lisbon was performed, regarding the patient's gender and age, type of biopsy, location of lesions, clinical and histological diagnosis, and the results were obtained. Association relationships were studied using the chi-square test and the Kruskal-Wallis test to correlate variables. P<0.05 was considered statistically significant. Results: From a total sample of 1448 patients, 826 (57.1%) were female, 610 (42.1%) were male, and 12 (0.8%) had no gender information, with a mean age of 50.14 years (standard deviation ± 17.61). The preferred location was the buccal mucosa, vestibule fundus and alveolar mucosa (20.7%). Benign lesions (BL) were the most common, in 82,8% of the cases, followed by oral potentially malignant disorders (OPMD) in 15,5%, and finally, malignant lesions (ML) in 1.7%. Focal fibrous hyperplasia was the most frequent diagnosis in the total sample (25.6%). In the young group, the most common entity was mucocele (34.0%), with a predominance of the lower lip (32.9%). In OPMD, leukoplakia was the most frequently diagnosed (48,7%). The most common ML was squamous cell carcinoma (92.0%), appearing mainly in the tongue (34.8%). A statistically significant relation between ML and older age was found. Conclusions: This study included biopsies analysed over a period of 20 years, being BL the main pathology to affect the oral cavity. Although less frequent, OPMD and ML should not be neglected and must be correctly diagnosed and treated. Key words:Oral biopsies, Oral and maxillofacial pathology, Oral medicine, Clinicopathological analysis, Epidemiological study, University clinic.

Hygienic-sanitary quality and antimicrobial sensitivity profile of Escherichia coli in milk and cheese sold illegally in municipalities of northern Mato Grosso, Brazil

Products such as milk and cheese produced by hand and sold by small producers in open markets and at home are a reality in Brazil, despite legal prohibitions. In many cases, this leads to the production of food without hygienic conditions, which may constitute an important source of transmission of foodborne diseases and a danger to public health. This study proposes to examine the hygienic-sanitary quality of milk and cheese sold illegally in municipalities of northern Mato Grosso, Brazil, to undertake a phenotypical investigation of the presence of resistance of isolated colonies to antimicrobials and to detect the production of ß-lactamase enzymes: extended-spectrum ß-lactamase (ESBL), AmpC ß-lactamases (AmpC) and carbapenemases. The 25 milk and 37 cheese samples analyzed were subjected to the most probable number (MPN) test, isolation on eosin-methylene blue agar (EMB) agar and Escherichia coli identification by biochemical tests and disk diffusion test. Results showed that 76% of the milk samples and 67.57% of the cheese samples had thermotolerant coliform counts above the value allowed by the legislation. The milk and cheese isolates showed 15.79 and 5.88% resistance, respectively, to at least one of the tested antimicrobials. No ß-lactamase enzyme production was observed in the isolates.

Characterization of suicidal behavior among children in a depressive episode: case series study / Caracterização do comportamento suicida em crianças em episódio depressivo: estudo de série de casos

Abstract Introduction Child suicidal behavior is related to specific childhood variations, constituting risk factors, including predisposing factors, internal factors, and environmental factors. Objective To characterize suicidal behavior among children aged 5 to 12 years diagnosed with a depressive episode. Methods Fifteen participants, aged 5 to 12, were assessed at a child and adolescent mental health center in Belo Horizonte, state of Minas Gerais, Brazil. All participants had a history of suicide attempt and were in a depressive episode at the time of assessment. Results Vulnerabilities related to the children themselves were self-harm, aggression, loss of an important family figure, sexual abuse, sexuality disorders, use of alcohol or other drugs, and ill-treatment. Factors of family structure and dynamics found were psychiatric illness in family members, family conflict or violence, abandonment or rejection, history of suicidal behavior in family, parents users of alcohol and other drugs, and separated parents. Factors related to school were bullying, school difficulties/delays, high school performance, bad behavior, physical aggression, school dropout, and aggressiveness. The main methods used in suicide attempts were injury by sharp or blunt objects and intentional self-poisoning. Conclusions Psychiatric comorbidities and a previous history of disturbances in the family and at school are important factors to consider with relation to suicidal behavior by children with depressive episodes.

Resumo Introdução O comportamento suicida infantil está relacionado com vicissitudes específicas da infância, representadas por fatores de risco, incluindo fatores predisponentes, internos e ambientais. Objetivo Caracterizar o comportamento suicida em crianças de 5 a 12 anos com diagnóstico de episódio depressivo. Métodos Quinze participantes, com idades entre 5 e 12 anos, foram avaliados em um centro de saúde mental da infância e adolescência de Belo Horizonte, MG, Brasil. Todos os participantes tinham histórico de tentativa de suicídio e estavam em um episódio depressivo no momento da avaliação. Resultados As vulnerabilidades relacionadas às próprias crianças foram automutilação, agressão, perda de uma figura familiar importante, abuso sexual, distúrbios da sexualidade, uso de álcool ou outras drogas e maus-tratos. Em relação a estrutura e dinâmica familiar, foram encontrados fatores como doença psiquiátrica na família, conflito ou violência familiar, abandono ou rejeição, histórico de comportamento suicida na família, pais usuários de álcool e outras drogas e pais separados. Os fatores relacionados à escola foram assédio moral, dificuldades/atrasos escolares, bom desempenho escolar, mau comportamento, agressão física, abandono escolar e agressividade. Os principais métodos utilizados nas tentativas de suicídio foram lesões por objetos pontiagudos ou contundentes e autoenvenenamento intencional. Conclusão As comorbidades psiquiátricas e o histórico prévio de distúrbios na família e na escola são fatores importantes a serem considerados em relação ao comportamento suicida em crianças com episódios depressivos.

Aesthetic Rehabilitation of a Patient with Bruxism Using Ceramic Veneers and Overlays Combined with Four-Point Monolithic Zirconia Crowns for Occlusal Stabilization: A 4-Year Follow-Up.

Management of severe worn dentition in patients with bruxism is challenging as a result of the loss of tooth structure and occlusal vertical dimension, temporomandibular implications, tooth hypersensitivity, and masticatory or aesthetic impairment. This case describes the 4-year follow-up clinical evaluation of a full mouth tooth-supported rehabilitation made on a 66-year-old man with bruxism and tooth wear, with aesthetic complaints and compromised masticatory function. The prosthetic treatment was planned with a digital smile design and a mock-up technique for an aesthetic and minimally invasive approach using lithium disilicate pressed and layered veneers on anterior teeth, posterior CAD/CAM lithium disilicate overlays with facial coverage, and CAD/CAM monolithic zirconia crowns with facial feldspathic ceramic on maxillary and mandibular canines and first molars in order to ensure the occlusal stability at the increased occlusal vertical dimension. After 4 years of function, no complications were registered. The choice of an appropriate material for the rehabilitation of these patients is essential to improve treatment prognosis and should be guided by mechanical and aesthetical properties. The use of four-point occlusal stabilization with CAD/CAM high strength monolithic zirconia crowns combined with ceramic veneers and overlays appears to be a reliable treatment option that enhances aesthetics and minimizes the occurrence of ceramic fractures, ensuring the treatment prognosis and predictability.

Characterization of suicidal behavior among children in a depressive episode: case series study.

INTRODUCTION: Child suicidal behavior is related to specific childhood variations, constituting risk factors, including predisposing factors, internal factors, and environmental factors. OBJECTIVE: To characterize suicidal behavior among children aged 5 to 12 years diagnosed with a depressive episode. METHODS: Fifteen participants, aged 5 to 12, were assessed at a child and adolescent mental health center in Belo Horizonte, state of Minas Gerais, Brazil. All participants had a history of suicide attempt and were in a depressive episode at the time of assessment. RESULTS: Vulnerabilities related to the children themselves were self-harm, aggression, loss of an important family figure, sexual abuse, sexuality disorders, use of alcohol or other drugs, and ill-treatment. Factors of family structure and dynamics found were psychiatric illness in family members, family conflict or violence, abandonment or rejection, history of suicidal behavior in family, parents users of alcohol and other drugs, and separated parents. Factors related to school were bullying, school difficulties/delays, high school performance, bad behavior, physical aggression, school dropout, and aggressiveness. The main methods used in suicide attempts were injury by sharp or blunt objects and intentional self-poisoning. CONCLUSIONS: Psychiatric comorbidities and a previous history of disturbances in the family and at school are important factors to consider with relation to suicidal behavior by children with depressive episodes.

Homeopatia na Graduação Médica: Trajetória da Universidade Federal Fluminense / Homeopathy in Medical Schools: Trajectory of the Universidade Federal Fluminense

RESUMO A medicina homeopática foi reconhecida pelo Conselho Federal de Medicina como especialidade médica em 1980 e desde então a presença de seu ensino na formação médica tem se ampliado no Brasil. Na graduação médica da Universidade Federal Fluminense (UFF), iniciou-se em 1994. Em estudo de caso com abordagem qualitativa, analisou-se a trajetória do ensino da Homeopatia no curso de Medicina da UFF utilizando-se análise documental, observação direta, entrevistas individuais de coordenadores e alunos, e grupo focal com ex-alunos das cinco disciplinas que abordam a medicina homeopática. Identificou-se uma trajetória de resistência e avanços, desencadeada no processo de reforma curricular em contexto de implantação do Sistema Único de Saúde (SUS) e ampliação da atenção primária. Apoiado na colaboração de profissionais externos à instituição, o ensino da Homeopatia na Medicina da UFF apresenta como principais desafios sua consolidação no currículo obrigatório, integração às demais clínicas, contratação de professores especialistas e recriação do ambulatório-escola em Homeopatia para prática supervisionada. A humanização da prática médica e a integralidade do cuidado foram suas contribuições mais mencionadas, numa perspectiva de integração e complementaridade da abordagem biomédica. Nas disciplinas obrigatórias, defende-se que os alunos possam desenvolver competências e habilidades para: (a) orientar e encaminhar pacientes à Homeopatia quando puderem ser beneficiados por esta medicina; (b) dialogar com colegas homeopatas no acompanhamento de pacientes comuns. As disciplinas optativas são importantes para alunos que queiram ampliar sua formação teórico-prática em Homeopatia, tendo em vista uma atuação profissional que inclua esta especialidade e lhes permita integrar os paradigmas vitalista e biomédico no cuidado em saúde. O ensino da Homeopatia na graduação médica da UFF é sustentado no compromisso de sua comunidade acadêmica com uma formação plural em saúde, capaz de propiciar aos futuros profissionais o uso de diferentes paradigmas para lidar com o processo de adoecimento, o corpo e as pessoas na sociedade contemporânea e, desta forma, contribuir para melhorar o relacionamento com pacientes, promover autonomia, diminuir abordagens invasivas e insensíveis, ampliar a integralidade do cuidado e a resolutividade do trabalho em saúde. O estudo crítico de sua trajetória oferece contribuições para uma reflexão sobre o ensino da Homeopatia também em outras escolas médicas, sejam as que já contemplem a Homeopatia em sua grade de disciplinas, sejam aquelas que estejam planejando inseri-la no currículo em resposta à demanda de alunos e professores.

ABSTRACT Homeopathic medicine was recognized by the Federal Council of Medicine as a medical specialty in 1980, and since then its teaching as part of medical training has grown in Brazil. Homeopathic medicine was first taight in Brazil in 1994 in the undergraduate medicine program of the Universidade Federal Fluminense (UFF). The history of teaching Homeopathy in the UFF medical course was analyzed in a qualitative-approach case study using documental analysis, direct observation, individual interviews with coordinators and students, and focus groups with alumni from five disciplines that address Homeopathy. The path identified involved resistance and progress, triggered by the curricular reform process in context of the implementation of the Brazilian Unified Health System (SUS) and the expansion of primary care. The teaching of Homeopathy in the UFF medical course was supported by the collaboration of external professionals. The major challenges included consolidating the discipline on the compulsory curriculum, acheiving integration with other clinics, hiring qualified teachers and recreating an outpatient Homeopathy school environment for supervised practice. From the perspective of integration and complementarity of the biomedical approach, humanized medical practice and comprehensive care were the most mentioned contributions. In the compulsory subjects it is argued that students can develop skills and abilities to: (a) guide and refer patients to Homeopathy whenever they might benefit from this medical practice; and (b) hold dialogues with homeopathy colleagues concerning the monitoring of common patients. The optional subjects are important for students who want to broaden their theoretical and practical training in Homeopathy, aimed at offering a professional practice that includes this specialty and permits the integration of the vitalist and biomedical paradigms in health care. The teaching of Homeopathy in the UFF undergraduate medical program is supported by its academic community's commitment to a plural health education that enables future professionals to use different paradigms for dealing with the disease process, the body and people in a contemporary society. This, in turn, contributes to improving relationships with patients, promotes autonomy, reduces invasive and insensitive approaches and expands comprehensive health care and resolute health work. This critical study of the trajectory of Homeopathy education in the UFF undergraduate medical course adds support to reflections on its teaching in other medical schools, including schools that already contemplate Homeopathy in their schedule or schools that are planning to include it in their curriculum in response to student and teacher demand.

Homeopatia na Graduação Médica: Trajetória da Universidade Federal Fluminense / Homeopathy in Medical Schools: Trajectory of the Universidade Federal Fluminense

RESUMO A medicina homeopática foi reconhecida pelo Conselho Federal de Medicina como especialidade médica em 1980 e desde então a presença de seu ensino na formação médica tem se ampliado no Brasil. Na graduação médica da Universidade Federal Fluminense (UFF), iniciou-se em 1994. Em estudo de caso com abordagem qualitativa, analisou-se a trajetória do ensino da Homeopatia no curso de Medicina da UFF utilizando-se análise documental, observação direta, entrevistas individuais de coordenadores e alunos, e grupo focal com ex-alunos das cinco disciplinas que abordam a medicina homeopática. Identificou-se uma trajetória de resistência e avanços, desencadeada no processo de reforma curricular em contexto de implantação do Sistema Único de Saúde (SUS) e ampliação da atenção primária. Apoiado na colaboração de profissionais externos à instituição, o ensino da Homeopatia na Medicina da UFF apresenta como principais desafios sua consolidação no currículo obrigatório, integração às demais clínicas, contratação de professores especialistas e recriação do ambulatório-escola em Homeopatia para prática supervisionada. A humanização da prática médica e a integralidade do cuidado foram suas contribuições mais mencionadas, numa perspectiva de integração e complementaridade da abordagem biomédica. Nas disciplinas obrigatórias, defende-se que os alunos possam desenvolver competências e habilidades para: (a) orientar e encaminhar pacientes à Homeopatia quando puderem ser beneficiados por esta medicina; (b) dialogar com colegas homeopatas no acompanhamento de pacientes comuns. As disciplinas optativas são importantes para alunos que queiram ampliar sua formação teórico-prática em Homeopatia, tendo em vista uma atuação profissional que inclua esta especialidade e lhes permita integrar os paradigmas vitalista e biomédico no cuidado em saúde. O ensino da Homeopatia na graduação médica da UFF é sustentado no compromisso de sua comunidade acadêmica com uma formação plural em saúde, capaz de propiciar aos futuros profissionais o uso de diferentes paradigmas para lidar com o processo de adoecimento, o corpo e as pessoas na sociedade contemporânea e, desta forma, contribuir para melhorar o relacionamento com pacientes, promover autonomia, diminuir abordagens invasivas e insensíveis, ampliar a integralidade do cuidado e a resolutividade do trabalho em saúde. O estudo crítico de sua trajetória oferece contribuições para uma reflexão sobre o ensino da Homeopatia também em outras escolas médicas, sejam as que já contemplem a Homeopatia em sua grade de disciplinas, sejam aquelas que estejam planejando inseri-la no currículo em resposta à demanda de alunos e professores.

ABSTRACT Homeopathic medicine was recognized by the Federal Council of Medicine as a medical specialty in 1980, and since then its teaching as part of medical training has grown in Brazil. Homeopathic medicine was first taight in Brazil in 1994 in the undergraduate medicine program of the Universidade Federal Fluminense (UFF). The history of teaching Homeopathy in the UFF medical course was analyzed in a qualitative-approach case study using documental analysis, direct observation, individual interviews with coordinators and students, and focus groups with alumni from five disciplines that address Homeopathy. The path identified involved resistance and progress, triggered by the curricular reform process in context of the implementation of the Brazilian Unified Health System (SUS) and the expansion of primary care. The teaching of Homeopathy in the UFF medical course was supported by the collaboration of external professionals. The major challenges included consolidating the discipline on the compulsory curriculum, acheiving integration with other clinics, hiring qualified teachers and recreating an outpatient Homeopathy school environment for supervised practice. From the perspective of integration and complementarity of the biomedical approach, humanized medical practice and comprehensive care were the most mentioned contributions. In the compulsory subjects it is argued that students can develop skills and abilities to: (a) guide and refer patients to Homeopathy whenever they might benefit from this medical practice; and (b) hold dialogues with homeopathy colleagues concerning the monitoring of common patients. The optional subjects are important for students who want to broaden their theoretical and practical training in Homeopathy, aimed at offering a professional practice that includes this specialty and permits the integration of the vitalist and biomedical paradigms in health care. The teaching of Homeopathy in the UFF undergraduate medical program is supported by its academic community's commitment to a plural health education that enables future professionals to use different paradigms for dealing with the disease process, the body and people in a contemporary society. This, in turn, contributes to improving relationships with patients, promotes autonomy, reduces invasive and insensitive approaches and expands comprehensive health care and resolute health work. This critical study of the trajectory of Homeopathy education in the UFF undergraduate medical course adds support to reflections on its teaching in other medical schools, including schools that already contemplate Homeopathy in their schedule or schools that are planning to include it in their curriculum in response to student and teacher demand.

Very Large Inflammatory Odontogenic Cyst with Origin on a Single Long Time Traumatized Lower Incisor.

One of the consequences of traumatic injuries is the chance of aseptic pulp necrosis to occur which in time may became infected and give origin to periapical pathosis. Although the apical granulomas and cysts are a common condition, there appearance as an extremely large radiolucent image is a rare finding. Differential diagnosis with other radiographic-like pathologies, such as keratocystic odontogenic tumour or unicystic ameloblastoma, is mandatory. The purpose of this paper is to report a very large radicular cyst caused by a single mandibular incisor traumatized long back, in a 60-year-old male. Medical and clinical histories were obtained, radiographic and cone beam CT examinations performed and an initial incisional biopsy was done. The final decision was to perform a surgical enucleation of a lesion, 51.4 mm in length. The enucleated tissue biopsy analysis was able to render the diagnosis as an inflammatory odontogenic cyst. A 2 year follow-up showed complete bone recovery.

Indexing and retrieving DICOM data in disperse and unstructured archives.

OBJECTIVE: This paper proposes an indexing and retrieval solution to gather information from distributed DICOM documents by allowing searches and access to the virtual data repository using a Google-like process. METHODS AND MATERIALS: The medical imaging modalities are becoming more powerful and less expensive. The result is the proliferation of equipment acquisition by imaging centers, including the small ones. With this dispersion of data, it is not easy to take advantage of all the information that can be retrieved from these studies. Furthermore, many of these small centers do not have large enough requirements to justify the acquisition of a traditional PACS. RESULTS: A peer-to-peer PACS platform to index and query DICOM files over a set of distributed repositories that are logically viewed as a single federated unit. The solution is based on a public domain document-indexing engine and extends traditional PACS query and retrieval mechanisms. CONCLUSION: This proposal deals well with complex searching requirements, from a single desktop environment to distributed scenarios. The solution performance and robustness were demonstrated in trials. The characteristics of presented PACS platform make it particularly important for small institutions, including educational and research groups.